Central Apparatus Structure Resolved

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mammalian sperm

Phys Org

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Science

In-situ structure of sperm central apparatus reveals molecular basis of male infertility

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In a study published in Cell Research , a research team has, for the first time, resolved the high-resolution in situ structure of the central apparatus ( CA ) within the axoneme of mammalian sperm.

CA is the microscopic engine that powers the movement of motile cilia and flagella.

This study marks the first comprehensive elucidation of the assembly mechanism of the CA in mammalian sperm and systematically explains how defects in CA proteins can impair flagellar motility.

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