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circular RNAsScienceDaily
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'Loophole' is a biological process that involves circular RNAs and marks the first experimental evidence of HIV-1 generating them from an integrated retroviral genome.
CircRNAs form a "loop" or circle inside cells -- unlike regular RNA molecules that are shaped like a straight line.
This looped shape makes circRNAs much more stable and enables them to act like sponges -- soaking up microRNAs (miRNAs) and preventing them from doing their usual jobs.
The research team plans to explore new treatments that use special molecules called antisense oligonucleotides (ASOs) to block HIV's circRNAs.
They'll test this approach in models of long-term infection and in cells from people living with HIV.
CircRNAs could also be used as markers of infection or as new targets for drugs.
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