Siglec-E Receptor Slows Inflammation
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innate immune systemScienceDaily
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Insights on preventing organ transplant rejection

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Researchers from Mass General Brigham identified a natural 'brake' within the innate immune system: the inhibitory receptor Siglec-E (SigE) and its human counterparts, Siglelc-7 and SigleC-9 .
This receptor helps prevent overactivation of immune cells that drive rejection.
When this brake is missing, inflammation worsens, leading to faster rejection in preclinical models.
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