Estrogen, Progeria Aid Pain Relief
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Estrogen may spur the body to make opioids after injury
88% Informative
Female sex hormones estrogen and progesterone work together to direct immune cells to make painkillers.
These cells then make their own painkillers, an opioid called enkephalin.
The opioids are released in response to nerve injuries, but only in females.
The research could help unravel sex differences in human pain perception, as well as how pain perception shifts during pregnancy.
The study raises questions about what might happen in menopause, when the body's production of female sex hormones plummets.
The study was funded, in part, by the National Institutes of Health .
The NIH has long upheld a policy that requires grantees to include both male and female animals in their research.
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