Mechanical Forces Control Fibrosis
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fibrosisScienceDaily
•Health
Health
The right moves to reign in fibrosis

78% Informative
Washington University in St. Louis has decoded how mechanical forces drive cell behavior in fibrosis.
Fibrosis is an affliction wherein cells produce excess fibrous tissue.
Fibroblast cells do this to close wounds, but the process can cascade in unwanted places.
Researchers sought to harness the power of these mechanical forces, using a strategic pull and tug in the right mix of directions.
"The next generation of disease we're going to be conquering are diseases of mechanics," Genin said.
Tension anisotropy drives fibroblast phenotypic transition by self-reinforcing cell-extracellular matrix mechanical feedback.
This work was supported by National Science Foundation Center for Engineering Mechanobiology grant CMMI-154857 ( G.M.G , V.B.G ), National Heart , Lung , and Blood Institute award R01HL159094 (N.H).
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