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The right moves to reign in fibrosis

ScienceDaily
Summary
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78% Informative

Washington University in St. Louis has decoded how mechanical forces drive cell behavior in fibrosis.

Fibrosis is an affliction wherein cells produce excess fibrous tissue.

Fibroblast cells do this to close wounds, but the process can cascade in unwanted places.

Researchers sought to harness the power of these mechanical forces, using a strategic pull and tug in the right mix of directions.

"The next generation of disease we're going to be conquering are diseases of mechanics," Genin said.

Tension anisotropy drives fibroblast phenotypic transition by self-reinforcing cell-extracellular matrix mechanical feedback.

This work was supported by National Science Foundation Center for Engineering Mechanobiology grant CMMI-154857 ( G.M.G , V.B.G ), National Heart , Lung , and Blood Institute award R01HL159094 (N.H).

VR Score

87

Informative language

92

Neutral language

60

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formal

Language

English

Language complexity

61

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not offensive

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not hateful

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Known propaganda techniques

not detected

Time-value

long-living

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