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fibrosisPhys Org
•Health
Health
88% Informative
Fibrosis is an affliction wherein cells produce excess fibrous tissue.
Fibroblast cells do this to close wounds, but the process can cascade in unwanted places.
WashU researchers harnessed the power of mechanical forces to tell the cell to shut off its excess fiber.
"The magnitude of tension will affect what the cell does," says Nathaniel Huebsch .
Alisafaei et al, Tension anisotropy drives fibroblast phenotypic transition by self-reinforcing cellextracellular matrix mechanical feedback, Nature Materials ( 2025 ). DOI: 10.1038 /s41563-025-02162-5 Journal information: Nature Materials Provided by Washington University in St. Louis .
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