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neurodegenerative diseasesScienceDaily
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New clue on what is leading to neurodegenerative diseases like Alzheimer's and ALS .
Decreased levels of TDP-43 gene inside the nucleus of endothelial cells is disrupting blood-brain barrier's protection.
The BBB serves as a critical protective barrier protecting the brain from circulating factors that could cause inflammation and dysfunction.
Story Source: Journal Reference: - Omar M. F. Omar, Amy L. Kimble , Ashok Cheemala , Jordan D. Tyburski , Swati Pandey , Qian Wu , Bo Reese , Evan R. Jellison , Bing Hao , Yunfeng Li , Riqiang Yan , Patrick A. Murphy . Endothelial TDP-43 depletion disrupts core bloodbrain barrier pathways in neurodegeneration. Nature Neuroscience, 2025 ; DOI: 10.1038 /s41593-025-01914-5 Cite This Page:.
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