In-cell UVPD-TDMS Protein Analysis

This is a news story, published by Phys Org, that relates primarily to UVPD news.

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Intracellular Protein Heterogeneity

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cell protein characterization

Phys Org

•

Science

Mass spectrometry method introduces novel concept for in-cell protein characterization

Summary

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Researchers combined in-cell MS with 193-nm UVPD to directly analyze protein structures within cells.

This method employed induced electrospray ionization, which ionizes intracellular proteins with minimal structural perturbation.

UVPD was applied to excite and dissociate protein backbones, generating abundant a-, b-, c, x-, y-, and z-fragment ions, which are rich in protein structure and interaction features.

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