Nasal Anti-CD3 Reduces Neuroinflammation
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Foralumab Nasal SprayMass General Brigham | Integrated Health Care System
•Science
Science
Nasal Spray Shows Preclinical Promise for Treating Traumatic Brain Injury
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91% Informative
A new study led by researchers at Mass General Brigham suggests a nasal spray developed to target neuroinflammation could one day be an effective treatment for traumatic brain injury.
The nasal anti-CD3 induces regulatory immune cells to travel up to the brain and come in contact with microglial cells to control inflammatory response.
The spray could reduce damage to the central nervous system and behavioral deficits.
Anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10 -dependent Tregmicroglia crosstalk.
Mass General Brigham is a nonprofit organization committed to patient care, research, teaching, and service to the community.
VR Score
92
Informative language
92
Neutral language
88
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formal
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English
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