Cancer Immunotherapy Target: Dysfunctional B Cells
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Scientists identify a new cancer immunotherapy target: Dysfunctional B cells
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University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood.
The finding gives oncologists a new target for developing immunotherapies: double negative memory B cells.
B cells are white blood cells, produced in the bone marrow, that neutralize pathogens.
This research was supported by the National Cancer Institute T 32 Cancer Immunology Training Program ( 2T32CA082084-16A1 ), UPMC Hillman Cancer Center Support Grant (P30CA047904), National Institute of Dental and Craniofacial Research (R01DE031729-01A1).
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