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viral RNAPhys Org
•Science
Science
88% Informative
Study paves the way for new therapies that can "unfreeze" these RNA structures to combat other mosquito-borne RNA viruses.
Researchers in the Qi Zhang's lab made the discovery back in 2017 , when they were performing routine imaging experiments using nuclear magnetic resonance ( NMR ) imaging.
Further investigation revealed that this frozen, stable RNA structure plays an important role in viral replication.
More information: Rhese D. Thompson et al, Lifetime of ground conformational state determines the activity of structured RNA , Nature Chemical Biology ( 2025 ). DOI: 10.1038 /s41589-025-01843-1 Journal information: Nature Chemical Biology .
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