Genomes Resilient to Structural Changes

This is a news story, published by Phys Org, that relates primarily to CRISPR news.

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human genomes

Phys Org

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Science

Complex engineering of human cell lines reveals genome's unexpected resilience to structural changes

Summary

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92% Informative

Scientists used CRISPR prime editing to create multiple versions of human genomes in cell lines, each with different structural changes.

Using genome sequencing, they were able to analyze the genetic effects of these structural variations on cell survival.

They found that as long as essential genes remain intact, our genomes can tolerate significant structural changes, including large deletions of the genetic code.

Structural variants are known to play roles in developmental diseases and cancer, but it has been difficult to study them experimentally.

The right mix of ingredients came together at the right time: the scale of genome sequencing, cutting-edge genome engineering, and the use of recombinases.

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semi-formal

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English

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