Senescent cells clog immune system

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Medical Xpress - medical research advances and health news

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Unclogging the immune system: Scientists use immunotherapy to remove aging cell buildup

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Senescent cells build up in the body by clogging up the immune system, thereby preventing their own removal.

Weizmann Institute of Science researchers have shown that getting rid of these cells might delay age-related diseases, reduce inflammation and extend lives.

They found that senescent cells from a mouse's lung express high quantities of proteins that repress immune system.

This protein, PD-L1, is a key target for development of new cancer drugs.

More information: Julia Majewska et al , p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells, Nature Cell Biology ( 2024 ). DOI: 10.1038 /s41556-024-01465-0 Provided by Weizmann Institute of ScienceThis story was originally published on Medical Xpress . Subscribe to our newsletter for the latest sci-tech news updates..

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