covalent RNA-ligand labeling technique

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RNA complexes

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intracellular RNA dynamics

Phys Org

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Science

Fluorescent RNA complexes offer new insights into cellular dynamics

Summary

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92% Informative

Researchers from the University of Innsbruck describe a structure-guided approach to the formation of covalent (i.e., irreversibly tethered) RNA-ligand complexes.

Key to this is the modification of the original ligand with a reactive "handle" that allows it to react with a nucleobase at the RNA binding site.

The versatility of the approach is highlighted by the first "fluorescent light-up RNA aptamer".

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English

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