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Science
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Stanford University scientists’ findings in mice could translate into a radical, needle-free vaccination approach that would also eliminate reactions including fever, swelling and pain.
Staphylococcus epidermidis, a generally harmless skin-colonizing bacterial species, hangs out on the skin of close to everyone on Earth .
Scientists turned S. epidermidis into a living, plug-and-play vaccine that can be applied topically.
They learned that the part of the protein responsible for tripping off a powerful immune response is a protein called Aap.
Aap is five times the size of an average protein, protrudes from the bacterial cell wall.
Topical application of this bug generated enough antibodies to protect mice from six times the lethal dose of tetanus toxin.
Fischbach expects to see this vaccination approach enter clinical trials within two or three years .
“We think this will work for viruses, bacteria, fungi and one -celled parasites,” he said.
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