Key regulator induces cancer-killing T cells
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cancer microenvironmentScienceDaily
•Key regulator that induces cancer-killing capacity in T cells under hypoxia is identified
80% Informative
Key regulator that induces cancer-killing capacity in T cells under hypoxia is identified.
University of Alabama at Birmingham researchers found that HIF1 -glycolysis is indispensable for IFN- induction in hypoxic T cells.
The cytokine IFN is known to be essential to induce the tumor killing capacity of T cells..
HIF1 function in T cells is a major T cell-intrinsic mechanism of therapeutic resistance to ICBs, like anti-CTLA-4 and anti-PD-1/L1.
Acacetate supplementation restored IFN- production in Hif1 -deletion-TILs.
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