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Key regulator that induces cancer-killing capacity in T cells under hypoxia is identified

ScienceDaily
Summary
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80% Informative

Key regulator that induces cancer-killing capacity in T cells under hypoxia is identified.

University of Alabama at Birmingham researchers found that HIF1 -glycolysis is indispensable for IFN- induction in hypoxic T cells.

The cytokine IFN is known to be essential to induce the tumor killing capacity of T cells..

HIF1 function in T cells is a major T cell-intrinsic mechanism of therapeutic resistance to ICBs, like anti-CTLA-4 and anti-PD-1/L1.

Acacetate supplementation restored IFN- production in Hif1 -deletion-TILs.

VR Score

89

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96

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55

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formal

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English

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78

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not offensive

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not hateful

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not detected

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long-living

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