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92% Informative
A simple dietary supplement may provide a new approach to boost CAR T cell function.
Beta-hydroxybutyrate, a metabolite produced by the liver in response to a ketogenic diet, was a key mediator of this effect.
CAR T cells prefer BHB as a fuel source rather than standard sugars in our body, such as glucose.
The BHB supplement is being tested in a clinical trial at Penn Medicine’s Abramson Cancer Center .
The study was partly funded by the Penn -CHOP Microbiome Core.
Liu will present the findings during the Plenary Scientific Session on Sunday, Dec. 8 at 2 p.m. PT.
Patients interested in clinical trials at the Abramson Cancer Center can search open clinical trials here.
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