Neuropilin-1 Receptor for Pain Signaling

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nerve growth factor pain signaling

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nerve growth factor

ScienceDaily

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Scientists discover new receptor for nerve growth factor--a promising target for treating pain

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Scientists discover new receptor for nerve growth factor--a promising target for treating pain.

Cellular studies reveal neuropilin-1 is required for signaling pain and may offer a new approach for developing or repurposing therapies to address chronic pain.

Nerve growth factor is a protein that stimulates the development of neurons.

NRP1 inhibitors -- including monoclonal antibodies -- have already been developed to treat cancer.

Researchers are harnessing their new understanding of the pain signaling complex to develop new peptide-based analgesics that prevent this signaling complex from forming.

The research was supported in part by the National Institutes of Health and the Department of Defense .

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