Gene Switch Affects Plant Development

This is a news story, published by ScienceDaily, that relates primarily to Aman Husbands news.

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From one gene switch, many possible outcomes

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University of Pennsylvania's Aman Husbands , of the School of Arts & Sciences , uncovered surprising ways transcription factors regulate plant development.

Their findings reveal how subtle changes in a lipid-binding region called the START domain can dramatically alter gene regulation, paving the way for advancements in crop engineering, synthetic biology, and precision gene therapies.

Researchers found that the START domain was the critical determinant for gene regulation.

By deleting, mutating, and swapping START domains, the researchers demonstrated that this region acted as a decision-making tool, dictating whether a gene was activated or suppressed.

The team is now exploring how this mechanism operates in other transcription factor families.

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