Regulates Cancer Cells' Macropinocytosis
This is a R01CA207189 news story, published by ScienceDaily, that relates primarily to Cosimo Commisso news.
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pancreatic cancer cellsScienceDaily
•Controlling cancer cells' gluttony for glutamine
81% Informative
Pancreatic ductal adenocarcinoma ( PDAC ) involves cancer cells reshaping their cell surfaces to snatch extra nutrients from the jelly-like substance between cells.
This cellular contortion is a process called macropinocytosis.
Blocking it and cutting off the energy and protein building blocks it provides has been shown to significantly suppress tumor growth.
"This work highlights how pancreatic cancer cells hijack cell polarity proteins to regulate macropinocytosis and tumor metabolism," says Cosimo Commisso .
The study was supported by the National Institutes of Health (R01CA254806 and R01CA207189 ) and National Cancer Institute .
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