Golgi Stress Affects T-Cells
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Golgi apparatus modifiesScienceDaily
•How Golgi stress affects T-cells' tumor-fighting ability
76% Informative
The Golgi apparatus modifies, sorts and packages proteins to be sent to their final destinations.
It's a core function, but little studied in the setting of cancer immunology, especially when compared to other organelles like the mitochondria or endoplasmic reticulum.
T-cells and CAR-T cells can become "exhausted" in the hostile tumor microenvironment.
This pre-clinical work suggests that sorting T-cells into Golgi-hi and Golgi Lo would create a better chance of controlling the tumor.
More work is also needed to understand the role of Golgi stress when all of the organelles in a cell are under stress because of the tumor microenvironment.
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