Mouse intestine immune system regulation

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entire mouse small intestine

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Scientists find a region of the mouse gut tightly regulated by the immune system

Summary

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80% Informative

Scientists find a region of the mouse gut tightly regulated by the immune system.

A spatial map of gene expression across the intestine reveals the organ's remarkable adaptability.

The findings suggest the gut's ability to bounce back from changes about changes about inflammation could be critical to intestinal health.

Using single-cell RNA sequencing, the authors found that the changes occurred in three structural cell types.

Goblet cells -- cup-shaped cells that secrete mucus -- expressed those genes only in the presence of ILC2s , a kind of immune cell.

The researchers plan to apply their method to study how other factors including sex, diet, food allergies, and genetic risk factors for conditions such as inflammatory bowel disease impact the intestine's spatial landscape.

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