CRISPR-Enabled Cell-to-Cell Analysis

This is a Mizuno news story, published by ScienceDaily, that relates primarily to New CRISPR news.

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extracellular vesicles

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small extracellular vesicles

ScienceDaily

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Labeling cell particles with barcodes

Summary

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New CRISPR -based system could help us better understand cell-to-cell communication with unprecedented efficiency.

The particles, known as small extracellular vesicles (sEVs), play an important role in the spread of disease and as potential drug carriers.

The newly developed system, named CIBER , enables thousands of genes to be studied at once, by labeling sEVs with a kind of RNA 'barcode'.

Story Source: Journal Reference: - Koki Kunitake , Tadahaya Mizuno , Kazuki Hattori , Chitose Oneyama , Mako Kamiya , Sadao Ota , Yasuteru Urano , Ryosuke Kojima . Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators. Nature Communications , 2024 ; 15 ( 1 ) DOI: 10.1038 /s41467-024-53736-x Cite This Page:.