FOXA1 Protein Drug Potential
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Forkhead box proteinPhys Org
•Scientists discover chemical probes for previously 'undruggable' cancer target
77% Informative
Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1) FOXA1 mutations can enable these types of cancers to grow and proliferate.
The team's findings also mapped out how tiny drug-like chemical compounds—called small molecules—interact with the protein.
Sang Joon Won, Yuxiang Zhang , Christopher J. Reinhardt , Lauren M. Hargis , Nicole S. MacRae , Kristen E. DeMeester and Jarrett R. Remsberg of The Scripps Research Institute are the authors of the study.
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