CRISPRmap: Optical Pooled Screening Approach

This is a news story, published by MSN, that relates primarily to Columbia news.

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Optical phenotypes

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optical readout assays

Phys Org

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Scientists develop a new method to study gene function in cells and tissue

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CRISPRmap enables the coupling of optical properties of single cells to targeted genetic perturbations.

Optical phenotypes are typically inaccessible for sequencing-based approaches based on cell lysis but include crucial information such as cell morphology, protein subcellular localization, cell-cell interactions, extracellular matrix factors, and tissue organization.

This approach opens new avenues for understanding genes involved in immune cell recruitment to tumors, metastasis, invasion, angiogenesis, etc..

DOI: 10.1038 /s41587-024-02386-x Provided by Columbia UniversityThis story was originally published on Phys.org . Subscribe to our newsletter for the latest sci-tech news updates..

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