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optical readout assaysPhys Org
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92% Informative
CRISPRmap enables the coupling of optical properties of single cells to targeted genetic perturbations.
Optical phenotypes are typically inaccessible for sequencing-based approaches based on cell lysis but include crucial information such as cell morphology, protein subcellular localization, cell-cell interactions, extracellular matrix factors, and tissue organization.
This approach opens new avenues for understanding genes involved in immune cell recruitment to tumors, metastasis, invasion, angiogenesis, etc..
DOI: 10.1038 /s41587-024-02386-x Provided by Columbia UniversityThis story was originally published on Phys.org . Subscribe to our newsletter for the latest sci-tech news updates..
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