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Gene therapyPsyPost
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76% Informative
COG-201 is an intranasal therapy based on short hairpin RNA (shRNA) This RNA molecule is designed to interfere with the expression of the serotonin 5 -HT2A receptor gene, reducing its activity in the brain.
The therapy was administered through a nasal spray, making it non-invasive and potentially easy to use in future clinical settings.
COG-201 may enhance the brain’s ability to coordinate information processing, which could explain the improvements in memory.
While individual neurons showed reduced activity, there was an increase in synchronized network activity among groups of neurons.
Researchers plan to continue studying the mechanisms behind the therapy and its potential to treat other conditions beyond mild cognitive impairment.
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84
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