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MicroRNA Revolutionizes Gene Regulation

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microRNA

The Conversation

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MicroRNA is the Nobel-winning master regulator of the genome – researchers are learning to treat disease by harnessing how it controls genes

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86% Informative

Nobel Prize recognition of microRNA molecules marks their importance in biology and their promise as potential treatments for various diseases, including cancer.

Victor Ambros and Gary Ruvkun discovered a new molecule they called microRNA in the 1980s .

Rather than translating DNA to proteins, they instead can bind to protein-coding RNAs to silence genes.

Andrea Kasinski : RNA -based treatments are generally short-lived in the body and require frequent doses to maintain a therapeutic effect.

Kasinski 's lab developed a new molecule called FolamiR-34a that reduced the size of breast and lung cancer tumors in mice.

Many labs are working to develop treatments based on the discoveries new Nobel laureates Ambros and Ruvkun made decades ago .

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English

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long-living

External references

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doi.org theconversation.com mirbase.org www.nobelprize.org creativecommons.org commons.wikimedia.org www.genome.gov www.ibiology.org www.ruvkun.hms.harvard.edu www.umassmed.edu scholar.google.com

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