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other schizophrenia treatmentsNature
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83% Informative
The drug, known as KarXT , targets proteins in the brain known as muscarinic receptors, which relay neurotransmitter signals between neurons and other cells.
Activating these receptors dampens the release of the chemical dopamine, a nervous-system messenger that is central to the hallmark symptoms of schizophrenia.
In clinical trials, KarXT showed signs of improving cognitive function, avoiding many of the burdensome side effects commonly associated with older antipsychotics.
Bristol Myers Squibb (BMS) in Princeton , New Jersey , acquired Karuna for approximately $14 billion this year .
Other drug makers are likewise seeing the value of targeting muscarinic receptors, pursuing various strategies to improve on the profile of KarXT .
Most industry analysts predict strong demand, with peak annual sales projected in the billions .
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