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Nature

Nature

Revolutionary drug for schizophrenia wins US approval

Nature
Summary
Nutrition label

83% Informative

The drug, known as KarXT , targets proteins in the brain known as muscarinic receptors, which relay neurotransmitter signals between neurons and other cells.

Activating these receptors dampens the release of the chemical dopamine, a nervous-system messenger that is central to the hallmark symptoms of schizophrenia.

In clinical trials, KarXT showed signs of improving cognitive function, avoiding many of the burdensome side effects commonly associated with older antipsychotics.

Bristol Myers Squibb (BMS) in Princeton , New Jersey , acquired Karuna for approximately $14 billion this year .

Other drug makers are likewise seeing the value of targeting muscarinic receptors, pursuing various strategies to improve on the profile of KarXT .

Most industry analysts predict strong demand, with peak annual sales projected in the billions .

VR Score

84

Informative language

85

Neutral language

53

Article tone

formal

Language

English

Language complexity

75

Offensive language

possibly offensive

Hate speech

not hateful

Attention-grabbing headline

not detected

Known propaganda techniques

not detected

Time-value

long-living

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