This is a UK news story, published by UK Research and Innovation, that relates primarily to the Medical Research Council Laboratory of Molecular Biology news.
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tau proteinsUK Research and Innovation
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81% Informative
Scientists are from the Medical Research Council Laboratory of Molecular Biology (MRC LMB), and the UK Dementia Research Institute ( UK DRI) at the University of Cambridge .
They say this promising approach for Alzheimer’s disease could also be applied in future to other brain disorders driven by protein aggregation inside cells.
The RING-Bait therapy was able to prevent tau aggregation induced by proteins from both Alzheimer’s and progressive supranuclear palsy patient brains.
Mice mice with tau protein aggregates were injected with a single dose of the gene therapy vector containing either the treatment, or a placebo.
Within a few weeks , there was a significant reduction in the amount of aggregated tau in the brain cells of the treated animals.
The progression of their neurodegeneration symptoms slowed and they showed significantly better motor function.
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