Lasso peptides' lasso-like stability
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lasso peptide substrateScienceDaily
•Researchers discover how enzymes 'tie the knot'
75% Informative
Lasso peptides are natural products made by bacteria.
Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions.
The structure of fusilassin cyclase, or FusC, remained unknown, making it impossible to understand how the cyclase interacts with the peptide to fold the knot.
As a proof-of-concept, they engineered a different cyclase, called McjC , to efficiently produce a potent inhibitor of a cancer-promoting integrin.
"The ability to generate lasso peptide diversity is important for optimizing drugs," said Mark Burk , CEO of Lassogen .
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