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Fever temperaturesScienceDaily
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80% Informative
Fever temperatures rev up immune cell metabolism, proliferation and activity, but also cause mitochondrial stress, DNA damage and cell death.
The findings offer a mechanistic understanding for how cells respond to heat and could explain how chronic inflammation contributes to the development of cancer.
The impact of fever temperatures on cells is a relatively understudied area.
The research was supported by the National Institutes of Health, Lupus Research Alliance , Waddell Walker Hancock Cancer Discovery Fund, and National Science Foundation .
Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation, the authors say.
The study was published in Science Immunology , 2024 ; 9 ( 99 ) DOI: 10.1126 /doi-10.1.
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