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Journal of Neuroscience

Journal of Neuroscience

Amyloid-β Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling

Journal of Neuroscience
Summary
Nutrition label

77% Informative

Neuronal excitatory synapses are located on small dendritic protrusions called spines.

Ca2+ influx through postsynaptic NMDA -type glutamate receptors (NMDARs) initiates signaling pathways that coordinate changes in spine structure and synaptic function.

In Alzheimer's disease, the pathological agent amyloid- (A) may impair learning and memory by biasing NMDAR signaling pathways toward LTD and spine elimination.

VR Score

84

Informative language

89

Neutral language

56

Article tone

formal

Language

English

Language complexity

84

Offensive language

possibly offensive

Hate speech

not hateful

Attention-grabbing headline

not detected

Known propaganda techniques

not detected

Time-value

long-living

External references

no external sources

Source diversity

no sources

Affiliate links

no affiliate links