Genes Affect Menopause Timing

This is a UK news story, published by ScienceDaily, that relates primarily to PNPLA8 news.

UK news

For more UK news, you can click here:

more UK news

PNPLA8 news

For more PNPLA8 news, you can click here:

more PNPLA8 news

men's health news

For more men's health news, you can click here:

more men's health news

ScienceDaily news

For more news from ScienceDaily, you can click here:

more news from ScienceDaily

About the Otherweb

Otherweb, Inc is a public benefit corporation, dedicated to improving the quality of news people consume. We are non-partisan, junk-free, and ad-free. We use artificial intelligence (AI) to remove junk from your news feed, and allow you to select the best health news, business news, entertainment news, and much more. If you like men's health news, you might also like this article about

menopause timing

. We are dedicated to bringing you the highest-quality news, junk-free and ad-free, about your favorite topics. Please come every day to read the latest earlier menopause news, menopause news, men's health news, and other high-quality news about any topic that interests you. We are working hard to create the best news aggregator on the web, and to put you in control of your news feed - whether you choose to read the latest news through our website, our news app, or our daily newsletter - all free!

underpinning menopause

ScienceDaily

•

Genes with strong impact on menopause timing also link to cancer risk

Summary

Nutrition label

80% Informative

New research has found four genes with some of the largest known effects on the timing of menopause discovered to date.

Researchers looked at variation in data from genetic sequencing of 106,973 post-menopausal female participants in the UK Biobank study.

Researchers focused on rare types of genetic changes which cause a loss of the protein.

When women only have one working copy of the four new genes identified (ETAA1, ZNF518A, PNPLA8 , PALB2 ), they have menopausal between two and five -and-a-half years earlier than average.

Strongest effect was found from gene variants in gene variants only found in one in 4,000 women.

Stasa Stankovic , Saleh Shekari , Qin Qin Huang , Eugene J Gardner , Erna V. Ivarsdottir , Nick D. Owens , Nasim Mavaddat , Ajuna Azad , Gareth Hawkes , Katherine A. Kentistou , Robin N. Beaumont , Felix R. Day, Yajie Zhao , Hakon Jonsson , Thorunn Rafnar , Vinicius Tragante , Gardar Sveinbjornsson , Asmundur Oddsson , Unnur Styrkarsdottiir , Julius Gudmundsson and Simon N. Stacey .