Do these 49ers have one last Super Bowl shot? The mental, physical and financial toll looms

The San Francisco 49ers open their season against the New York Jets on Monday night .

The 49ers lost to the Kansas City Chiefs in Super Bowl LVIII in February .

The pain of climbing the postseason mountain again cuts deeper because of the four misses in the past five seasons .

The toll of those disappointments -- mentally, physically and financially -- weigh heavily on these 49ers.

The 49ers were one of the healthiest teams in the NFL in 2023 .

After multiple injury-plagued seasons, the 49ers had 34.5 adjusted games lost (which estimates the impact of injuries on teams) It was the first time in 10 seasons that the Niners ranked better than 20th in the league's injury-prevention category.

The 49ers will have the worst rest differential in the NFL with 21 fewer days of rest than their opponents.

They'll face four teams coming off their byes, with only the Indianapolis Colts having more than two .

49ers are one of the most-traveled teams with 24,575 miles ( fifth most in NFL ) ESPN Analytics gives the 49ers the best chance to win Super Bowl LIX .