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Toxicity studiesScienceDaily
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79% Informative
Some per- and polyfluoroalkyl substances ( PFAS ) are poorly degradable and are also known as 'forever chemicals' They adversely affect health and can lead to liver damage, obesity, hormonal disorders, and cancer.
A research team from the Helmholtz Centre for Environmental Research ( UFZ ) has investigated the effects of PFAS on the brain.
Using a combination of modern molecular biology methods and the zebrafish model, the researchers revealed the mechanism of action and identified the genes involved.
When the researchers removed PFOS or PFHxS, hyperactivity subsided.
The method can be used to assess the risk of chemicals in the environment, including PFAS .
Using knockdown zebrafish, the researchers identified two genes from the ppar group that mediate the behaviour triggered by PFOS .
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