Ketamine Enhances Opioid Receptors
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glutamate receptor antagonistHome | Molecular Pharmacology
•Ketamine and major ketamine metabolites function as allosteric modulators of opioid receptors
81% Informative
Ketamine is a glutamate receptor antagonist that was developed over 50 years ago as an anesthetic agent.
At subanesthetic doses, ketamine and some metabolites are analgesics and fast-acting antidepressants, presumably through targets other than glutamate receptors.
All three opioid receptors (mu, delta, and kappa) showed synergism with submicromolar concentrations of ketamine .
This allosteric activity may contribute to ketamine’s therapeutic effectiveness for treating acute and chronic pain.
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