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molecule erases memoriesScientific American
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81% Informative
PKMzeta (protein kinase Mzeta ) made a big splash when a 2006 study showed blocking it erased memories for places in rats.
A new study published in Science Advances by SUNY Downstate Health Sciences University plugs holes in theory.
The findings boost a theory that has seen some pushback.
Researchers used two different molecules to block PKMzeta and KIBRA from interacting.
Both blockers reversed LTP and disrupted memories in normal mice, but had no effect on memory storage in mice engineered to lack PKmzeta .
Researchers think PKCiota /lambda is an evolutionary relic that was involved in memory.
There are also some types of memory that do not depend on PKMzeta .
Nobody knows what molecules are involved in those cases.
Fenton: There’s a molecular logic of how you make a long-lasting memory that can be carried out in multiple ways with different components.
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