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DNA methylation patternScienceDaily
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77% Informative
Second genetic sensor for DNA methylation discovered.
Epigenetic modifications can act as on-off switches to regulate gene expression and help generate diverse cell types without changing the underlying DNA sequence.
Discovery fills in a major gap in the field of epigenetics, says Rockefeller University's Funabiki lab.
In this new model, CDCA7 recognizes hemimethylated DNA in chromatin and recruits HELLS to the site.
HELLS slides the nucleosome out of the way, revealing the hemimmethylation site to UHRF1 .
The handover of hemimeteration sensing indicates that CDCA 7 is better at detecting hemimethyation within the dense heterochromatin than UHRf1 is.
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