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Featured Podcast EpisodesThe Other Web

Alex Fink

Zuckerman vs Zuckerberg

July 14, 2024

Ethan Zuckerman is a professor at the University of Massachusetts Amherst and a scholar of digital media. He and his team work to understand the contemporary digital world and build social media systems that are focused on communities, not on profits. Ethan is currently suing Meta (i.e. Facebook) in a landmark case that might (and likely should) change our interpretation of section 230. Please tune in to hear the details of the case and the various ways it could change the social media landscape. It's fascinating!

Prof. Jeff Jarvis - Rewriting Media's Business Model (Yet Again)

May 24, 2024

Jeff Jarvis is a journalism professor at the City College in New York (CUNY), the author of six books, and the cohost of the successful podcast "This week in Google and AI". Jeff spent many years teaching entrepreneurial journalism - and God knows journalism could use some entrepreneurial spirit, right about now. Please check out Jeff's books, The Gutenberg Parenthesis and Magazine, both from Bloomsbury (discount codes here: gutenbergparenthesis.com).

Donald Robertson - Where Philosophy Meets Psychology

June 22, 2024

Our guest today is Donald Robertson - Donald is a cognitive-behavioral psychotherapist and author of several books, including How to Think Like a Roman Emperor and, more recently, Marcus Aurelius: The Stoic Emperor. He is one of the founders of the Modern Stoicism nonprofit organization and the founder and president of the Plato's Academy Centre in Athens, Greece. He was born in Scotland but now lives in Montreal, Canada. His upcoming book, How to Think Like Socrates, will be released later this year, and can be preordered on Amazon, Barnes and Noble, or anywhere else books are generally sold.

Rick Edmonds - Analyzing the Financial Decline of Legacy Media

July 8, 2024

Rick Edmonds is the media business analyst for the Poynter Institute, a school and study center for working journalists. He has been doing research and writing for 25 years on the financial decline of legacy media, newspapers particularly, and the rise of new media alternatives. His reporting and commentary appear regularly on the Poynter Online site. He has spoken to conference groups in the U.S.A. and in Paris, Norway, Madrid, Vienna and Chile.

Jonathan Green - How To Make ChatGPT and Other Tools Useful (Right Now)

July 5, 2024

Welcome to the Otherweb. Our guest today is Jonathan Green - a bestselling author of hundreds of books, a celebrity ghostwriter, and an expert in using artificial intelligence tools to their utmost capacity. This is the best conversation I've had on the practical implications of ChatGPT and how regular people can augment their own capabilities by using these tools as a shortcut.

1h 4m

📌 Transition, Rafael Hits Cuba, More

Angela Palmer

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TOP STORY

TOP STORY

Trump, White House prepare for transition

WORLD

WORLD

Rafael lashes Cuba, power grid collapse

US POLITICS

US POLITICS

N.D. sends first woman to US House

All Stories

Summary

Article Metadata

Ecklonia Cava Polyphenols Affect Parkinson's

This is a news story, published by MDPI, that relates primarily to Cul3 news.

Cul3 news

For more Cul3 news, you can click here:

disease research news

For more disease research news, you can click here:

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About the Otherweb

Otherweb, Inc is a public benefit corporation, dedicated to improving the quality of news people consume. We are non-partisan, junk-free, and ad-free. We use artificial intelligence (AI) to remove junk from your news feed, and allow you to select the best health news, business news, entertainment news, and much more. If you like disease research news, you might also like this article about

Ecklonia cava Polyphenols

. We are dedicated to bringing you the highest-quality news, junk-free and ad-free, about your favorite topics. Please come every day to read the latest Modulates Parkinson news, Parkinson disease news, disease research news, and other high-quality news about any topic that interests you. We are working hard to create the best news aggregator on the web, and to put you in control of your news feed - whether you choose to read the latest news through our website, our news app, or our daily newsletter - all free!

Human Neuroblastoma Cells

MDPI

MDPI

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Ecklonia cava Polyphenols Have a Preventive Effect on Parkinson’s Disease through the Activation of the Nrf2-ARE Pathway

MDPI

Summary

Nutrition label

88% Informative

Ecklonia cava Polyphenols Have a Preventive Effect on Parkinson’s Disease through the Activation of the Nrf2-ARE Pathway Pathway.

ECP(L) group was treated with a low concentration of ECP ( 20 mg/kg body weight) and a high concentration ( 240mg/kg ) group.

Results: Effects of Rotenone and ECP on SH-SY5Y Cell Viability , Intracellular ROS Production , Motor Function and Morphology of Mouse Colon Mucosa.

The Nrf2/ARE Pathway : A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson’s Disease.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3 -based E3 ligase to regulate proteasomal degradation.

A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6 -OHDA-Induced Oxidative Stress in SH-SY5Y cells.

Ecklonia cava polyphenol protects the liver against ethanol-induced injury in rats.

A physiological threshold for protection against menadione toxicity by human NAD(P)H:quinone oxidoreductase in Chinese hamster ovary ( CHO ) cells.

VR Score

94

Informative language

95

Neutral language

65

Article tone

formal

Language

English

Language complexity

43

Offensive language

not offensive

Hate speech

not hateful

Attention-grabbing headline

not detected

Known propaganda techniques

not detected

Time-value

long-living

External references

121

https://doi.org/10.1111/acel.13031 https://www.ncbi.nlm.nih.gov/pubmed/26998193 https://scholar.google.com/scholar_lookup?title=Inprovement+of+learning+behavior+of+mice+by+an+antiacetylcholineesterase+and+neuroprotective+agent+NX42,+a+Laminariales-alge+extract.+Korean&author=Lee,+B.H.&author=Stein,+S.M.&publication_year=2004&journal=J.+Food+Aci.+Technol.&volume=36&pages=974%E2%80%93978 https://doi.org/10.1016/j.phrs.2008.03.004 https://scholar.google.com/scholar_lookup?title=GSK-3beta+acts+upstream+of+Fyn+kinase+in+regulation+of+nuclear+export+and+degradation+of+NF-E2+related+factor+2&author=Jain,+A.K.&author=Jaiswal,+A.K.&publication_year=2007&journal=J.+Biol.+Chem.&volume=282&pages=16502%E2%80%9316510&doi=10.1074/jbc.M611336200 https://scholar.google.com/scholar_lookup?title=Neuroprotective+effect+of+cajaninstilbene+acid+against+cerebral+ischemia+and+reperfusion+damages+by+activating+AMPK/Nrf2+pathway&author=Xu,+H.&author=Shen,+J.&author=Xiao,+J.&author=Chen,+F.&author=Wang,+M.&publication_year=2021&journal=J.+Adv.+Res.&volume=34&pages=199%E2%80%93210&doi=10.1016/j.jare.2020.07.011&pmid=35024191 https://doi.org/10.3389/fnmol.2023.1193590 https://scholar.google.com/scholar_lookup?title=Neurodegeneration+of+mouse+nigrostriatal+dopaminergic+system+induced+by+repeated+oral+administration+of+rotenone+is+prevented+by+4-phenylbutyrate,+a+chemical+chaperone&author=Inden,+M.&author=Kitamura,+Y.&author=Takeuchi,+H.&author=Yanagida,+T.&author=Takata,+K.&author=Kobayashi,+Y.&author=Taniguchi,+T.&author=Yoshimoto,+K.&author=Kaneko,+M.&author=Okuma,+Y.&publication_year=2007&journal=J.+Neurochem.&volume=101&pages=1491%E2%80%931504&doi=10.1111/j.1471-4159.2006.04440.x&pmid=17459145 https://doi.org/10.1111/jnc.13691 https://www.ncbi.nlm.nih.gov/pubmed/33808343 https://scholar.google.com/scholar_lookup?title=Compartmentalized+oxidative+stress+in+dopaminergic+cell+death+induced+by+pesticides+and+complex+I+inhibitors:+Distinct+roles+of+superoxide+anion+and+superoxide+dismutases&author=Rodriguez-Rocha,+H.&author=Garcia-Garcia,+A.&author=Pickett,+C.&author=Li,+S.&author=Jones,+J.&author=Chen,+H.&author=Webb,+B.&author=Choi,+J.&author=Zhou,+Y.&author=Zimmerman,+M.C.&publication_year=2013&journal=Free+Radic.+Biol.+Med.&volume=61&pages=370%E2%80%93383&doi=10.1016/j.freeradbiomed.2013.04.021 https://scholar.google.com/scholar_lookup?title=Regulatory+mechanisms+controlling+gene+expression+mediated+by+the+antioxidant+response+element&author=Nguyen,+T.&author=Sherratt,+P.J.&author=Pickett,+C.B.&publication_year=2003&journal=Annu.+Rev.+Pharmacol.+Toxicol.&volume=43&pages=233%E2%80%93260&doi=10.1146/annurev.pharmtox.43.100901.140229&pmid=12359864 https://scholar.google.com/scholar_lookup?title=Overview+of+Parkinson%E2%80%99s+disease&author=Lew,+M.&publication_year=2007&journal=Pharmacotherapy&volume=27&pages=155s%E2%80%93160s&doi=10.1592/phco.27.12part2.155S&pmid=18041935 https://scholar.google.com/scholar_lookup?title=Enteric+glial+cells:+New+players+in+Parkinson%E2%80%99s+disease?&author=Clairembault,+T.&author=Leclair-Visonneau,+L.&author=Neunlist,+M.&author=Derkinderen,+P.&publication_year=2015&journal=Mov.+Disord.&volume=30&pages=494%E2%80%93498&doi=10.1002/mds.25979 https://doi.org/10.1128/MCB.24.16.7130-7139.2004 https://scholar.google.com/scholar_lookup?title=Ecklonia+cava+polyphenol+protects+the+liver+against+ethanol-induced+injury+in+rats&author=Takahashi,+M.&author=Satake,+N.&author=Yamashita,+H.&author=Tamura,+A.&author=Sasaki,+M.&author=Matsui-Yuasa,+I.&author=Tabuchi,+M.&author=Akahoshi,+Y.&author=Terada,+M.&author=Kojima-Yuasa,+A.&publication_year=2012&journal=Biochim.+Biophys.+Acta&volume=1820&pages=978%E2%80%93988&doi=10.1016/j.bbagen.2012.02.008 https://scholar.google.com/scholar_lookup?title=Therapeutic+effects+of+phlorotannins+in+te+treatment+of+neurodegenerative+disorders&author=Kwon,+Y.J.&author=Kwon,+O.I.&author=Hwang,+H.J.&author=Shin,+H.C.&author=Yang,+S.&publication_year=2023&journal=Front.+Mol.+Neurosci.&volume=16&pages=1193590&doi=10.3389/fnmol.2023.1193590&pmid=37305552 https://doi.org/10.1073/pnas.172398899 https://doi.org/10.1038/nrdp.2017.13 https://scholar.google.com/scholar_lookup?title=The+clinical+symptoms+of+Parkinson%E2%80%99s+disease&author=Sveinbjornsdottir,+S.&publication_year=2016&journal=J.+Neurochem.&volume=139&pages=318%E2%80%93324&doi=10.1111/jnc.13691&pmid=27401947 https://scholar.google.com/scholar_lookup?title=Ecklonia+cava+polyphenol+has+a+protective+effect+against+ethanol-induced+liver+injury+in+a+cyclic+AMP-dependent+manner&author=Yamashita,+H.&author=Goto,+M.&author=Matsui-Yuasa,+I.&author=Kojima-Yuasa,+A.&publication_year=2015&journal=Mar.+Drugs&volume=13&pages=3877%E2%80%933891&doi=10.3390/md13063877&pmid=26096275 https://www.ncbi.nlm.nih.gov/pubmed/12359864 https://www.ncbi.nlm.nih.gov/pubmed/12193649 https://www.ncbi.nlm.nih.gov/pubmed/18455424 https://doi.org/10.1007/s12272-017-0948-4 https://scholar.google.com/scholar_lookup?title=The+Parkinson+Pandemic-A+Call+to+Action&author=Dorsey,+E.R.&author=Bloem,+B.R.&publication_year=2018&journal=JAMA+Neurol.&volume=75&pages=9%E2%80%9310&doi=10.1001/jamaneurol.2017.3299&pmid=29131880 https://doi.org/10.1128/MCB.00118-16 https://doi.org/10.3390/antiox10040539 https://www.ncbi.nlm.nih.gov/pubmed/27401947 https://doi.org/10.1016/j.jare.2020.07.011 https://scholar.google.com/scholar_lookup?title=Oxidative+stress+sensor+Keap1+functions+as+an+adaptor+for+Cul3-based+E3+ligase+to+regulate+proteasomal+degradation+of+Nrf2&author=Kobayashi,+A.&author=Kang,+M.I.&author=Okawa,+H.&author=Ohtsuji,+M.&author=Zenke,+Y.&author=Chiba,+T.&author=Igarashi,+K.&author=Yamamoto,+M.&publication_year=2004&journal=Mol.+Cell.+Biol.&volume=24&pages=7130%E2%80%937139&doi=10.1128/MCB.24.16.7130-7139.2004&pmid=15282312 https://scholar.google.com/scholar_lookup?title=Recent+advances+in+pharmacological+research+on+Ecklonia+species:+A+review&author=Koirala,+P.&author=Jung,+H.A.&author=Choi,+J.S.&publication_year=2017&journal=Arch.+Pharm.+Res.&volume=40&pages=981%E2%80%931005&doi=10.1007/s12272-017-0948-4&pmid=28840539 https://doi.org/10.1111/j.1365-2990.2007.00874.x https://www.ncbi.nlm.nih.gov/pubmed/16551619 https://scholar.google.com/scholar_lookup?title=Dieckol,+a+phlorotannin+isolated+from+a+brown+seaweed,+Ecklonia+cava,+inhibits+adipogenesis+through+AMP-activated+protein+kinase+(AMPK)+activation+in+3T3-L1+preadipocytes&author=Ko,+S.C.&author=Lee,+M.&author=Lee,+J.-H.&author=Lee,+S.-H.&author=Lim,+Y.&author=Jeon,+Y.-J.&publication_year=2013&journal=Environ.+Toxicol.+Pharmacol.&volume=36&pages=1253%E2%80%931260 https://scholar.google.com/scholar_lookup?title=Antioxidative+properties+of+brown+algae+polyphenolics+and+their+perspectives+as+chemopreventive+agents+against+vascular+risk+factors&author=Kang,+K.&author=Park,+Y.&author=Hwang,+H.J.&author=Kim,+S.H.&author=Lee,+J.G.&author=Shin,+H.C.&publication_year=2003&journal=Arch.+Pharm.+Res.&volume=26&pages=286%E2%80%93293&doi=10.1007/BF02976957&pmid=12735686 https://doi.org/10.1038/nrm3311 https://scholar.google.com/scholar_lookup?title=Bromocriptine+activates+NQO1+via+Nrf2-PI3K/Akt+signaling:+Novel+cytoprotective+mechanism+against+oxidative+damage&author=Lim,+J.H.&author=Kim,+K.M.&author=Kim,+S.W.&author=Hwang,+O.&author=Choi,+H.J.&publication_year=2008&journal=Pharmacol.+Res.&volume=57&pages=325%E2%80%93331&doi=10.1016/j.phrs.2008.03.004&pmid=18455424 https://scholar.google.com/scholar_lookup?title=Mitochondrial+dysfunction+in+Parkinson%E2%80%99s+disease:+Pathogenesis+and+neuroprotection&author=Mounsey,+R.B.&author=Teismann,+P.&publication_year=2010&journal=Parkinsons+Dis.&volume=2011&pages=617472&doi=10.4061/2011/617472&pmid=21234411 https://scholar.google.com/scholar_lookup?title=Gut-brain+and+brain-gut+axis+in+Parkinson%E2%80%99s+disease+models:+Effects+of+a+uridine+and+fish+oil+diet&author=Perez-Pardo,+P.&author=Dodiya,+H.B.&author=Broersen,+L.M.&author=Douna,+H.&author=van+Wijk,+N.&author=Lopes+da+Silva,+S.&author=Garssen,+J.&author=Keshavarzian,+A.&author=Kraneveld,+A.D.&publication_year=2018&journal=Nutr.+Neurosci.&volume=21&pages=391%E2%80%93402&doi=10.1080/1028415X.2017.1294555&pmid=28276272 https://www.ncbi.nlm.nih.gov/pubmed/35024191 https://doi.org/10.1016/j.jep.2023.116785 https://scholar.google.com/scholar_lookup?title=Direct+evidence+that+sulfhydryl+groups+of+Keap1+are+the+sensors+regulating+induction+of+phase+2+enzymes+that+protect+against+carcinogens+and+oxidants&author=Dinkova-Kostova,+A.T.&author=Holtzclaw,+W.D.&author=Cole,+R.N.&author=Itoh,+K.&author=Wakabayashi,+N.&author=Katoh,+Y.&author=Yamamoto,+M.&author=Talalay,+P.&publication_year=2002&journal=Proc.+Natl.+Acad.+Sci.+USA&volume=99&pages=11908%E2%80%9311913&doi=10.1073/pnas.172398899&pmid=12193649 https://doi.org/10.4061/2011/314082 https://www.ncbi.nlm.nih.gov/pubmed/22436748 http://www.ncbi.nlm.nih.gov/tools/primer-blast/https://doi.org/10.1074/jbc.M110.118976 https://scholar.google.com/scholar_lookup?title=Parkinson%E2%80%99s+disease:+A+dual-hit+hypothesis&author=Hawkes,+C.H.&author=Del+Tredici,+K.&author=Braak,+H.&publication_year=2007&journal=Neuropathol.+Appl.+Neurobiol.&volume=33&pages=599%E2%80%93614&doi=10.1111/j.1365-2990.2007.00874.x https://doi.org/10.1038/srep00898 https://scholar.google.com/scholar_lookup?title=ROS+and+ROS-Mediated+Cellular+Signaling&author=Zhang,+J.&author=Wang,+X.&author=Vikash,+V.&author=Ye,+Q.&author=Wu,+D.&author=Liu,+Y.&author=Dong,+W.&publication_year=2016&journal=Oxid.+Med.+Cell.+Longev.&volume=2016&pages=350965&doi=10.1155/2016/4350965&pmid=26998193 https://www.ncbi.nlm.nih.gov/pubmed/17459145 https://scholar.google.com/scholar_lookup?title=Total+saponins+from+Panax+japonicus+attenuate+acute+alcoholic+liver+oxidative+stress+and+hepatosteatosis+by+p62-related+Nrf2+pathway+and+AMPK-ACC/PPAR%CE%B1+axis+in+vivo+and+in+vitro&author=Qiu,+L.&author=Feng,+R.&author=Wu,+Q.S.&author=Wan,+J.B.&author=Zhang,+Q.W.&publication_year=2023&journal=J.+Ethnopharmacol.&volume=317&pages=116785&doi=10.1016/j.jep.2023.116785 https://doi.org/10.1111/j.1471-4159.2006.04440.x https://doi.org/10.1101/gad.13.1.76 https://scholar.google.com/scholar_lookup?title=Parkinson+disease&author=Poewe,+W.&author=Seppi,+K.&author=Tanner,+C.M.&author=Halliday,+G.M.&author=Brundin,+P.&author=Volkmann,+J.&author=Schrag,+A.-E.&author=Lang,+A.E.&publication_year=2017&journal=Nat.+Rev.+Dis.+Primers&volume=3&pages=17013&doi=10.1038/nrdp.2017.13&pmid=28332488 https://www.ncbi.nlm.nih.gov/pubmed/12735686 https://doi.org/10.1155/2016/4350965 https://scholar.google.com/scholar_lookup?title=Pyrroloquinoline+quinone+promotes+mitochondrial+biogenesis+in+rotenone-induced+Parkinson%E2%80%99s+disease+model+via+AMPK+activation&author=Cheng,+Q.&author=Chen,+J.&author=Guo,+H.&author=Lu,+J.L.&author=Zhou,+J.&author=Guo,+X.Y.&author=Shi,+Y.&author=Zhang,+Y.&author=Yu,+S.&author=Zhang,+Q.&publication_year=2021&journal=Acta+Pharmacol.+Sin.&volume=42&pages=665%E2%80%93678&doi=10.1038/s41401-020-0487-2 https://www.ncbi.nlm.nih.gov/pubmed/12429349 https://scholar.google.com/scholar_lookup?title=Parkinson%E2%80%99s+disease+and+the+gut:+A+well+known+clinical+association+in+need+of+an+effective+cure+and+explanation&author=Natale,+G.&author=Pasquali,+L.&author=Ruggieri,+S.&author=Paparelli,+A.&author=Fornai,+F.&publication_year=2008&journal=Neurogastroenterol.+Motil.&volume=20&pages=741%E2%80%93749&doi=10.1111/j.1365-2982.2008.01162.x&pmid=18557892 https://www.ncbi.nlm.nih.gov/pubmed/28332488 https://www.ncbi.nlm.nih.gov/pubmed/28840539 https://doi.org/10.1016/j.freeradbiomed.2013.04.021 https://doi.org/10.1038/nrneurol.2015.197 https://scholar.google.com/scholar_lookup?title=Glycogen+synthase+kinase-3beta+inhibits+the+xenobiotic+and+antioxidant+cell+response+by+direct+phosphorylation+and+nuclear+exclusion+of+the+transcription+factor+Nrf2&author=Salazar,+M.&author=Rojo,+A.I.&author=Velasco,+D.&author=de+Sagarra,+R.M.&author=Cuadrado,+A.&publication_year=2006&journal=J.+Biol.+Chem.&volume=281&pages=14841%E2%80%9314851&doi=10.1074/jbc.M513737200&pmid=16551619 https://doi.org/10.4061/2011/617472 https://doi.org/10.1016/j.jnutbio.2024.109586 https://scholar.google.com/scholar_lookup?title=Environmental+toxins+trigger+PD-like+progression+via+increased+alpha-synuclein+release+from+enteric+neurons+in+mice&author=Pan-Montojo,+F.&author=Schwarz,+M.&author=Winkler,+C.&author=Arnhold,+M.&author=O%E2%80%99Sullivan,+G.A.&author=Pal,+A.&author=Said,+J.&author=Marsico,+G.&author=Verbavatz,+J.-M.&author=Rodrigo-Angulo,+M.&publication_year=2012&journal=Sci.+Rep.&volume=2&pages=898&doi=10.1038/srep00898&pmid=23205266 https://www.ncbi.nlm.nih.gov/pubmed/18557892 https://scholar.google.com/scholar_lookup?title=Seaweeds%E2%80%99+neuroprotective+potential+set+in+vitro+on+a+human+cellular+stress+model&author=Silva,+J.&author=Alves,+C.&author=Pinteus,+S.&author=Mendes,+S.&author=Pedrosa,+R.&publication_year=2020&journal=Mol.+Cell.+Biochem.&volume=473&pages=229%E2%80%93238&doi=10.1007/s11010-020-03824-5 https://doi.org/10.1146/annurev.pharmtox.43.100901.140229 https://www.ncbi.nlm.nih.gov/pubmed/12496265 https://doi.org/10.1111/jrh.12154 https://doi.org/10.1038/s41401-020-0487-2 https://scholar.google.com/scholar_lookup?title=A+Flavonoid-Rich+Extract+of+Mandarin+Juice+Counteracts+6-OHDA-Induced+Oxidative+Stress+in+SH-SY5Y+Cells+and+Modulates+Parkinson-Related+Genes&author=Cirmi,+S.&author=Maugeri,+A.&author=Lombardo,+G.E.&author=Russo,+C.&author=Musumeci,+L.&author=Gangemi,+S.&author=Calapai,+G.&author=Barreca,+D.&author=Navarra,+M.&publication_year=2021&journal=Antioxidants&volume=10&pages=539&doi=10.3390/antiox10040539&pmid=33808343 https://www.ncbi.nlm.nih.gov/pubmed/22233888 https://scholar.google.com/scholar_lookup?title=AMPK+Facilitates+Nuclear+Accumulation+of+Nrf2+by+Phosphorylating+at+Serine+550&author=Joo,+M.S.&author=Kim,+W.D.&author=Lee,+K.Y.&author=Kim,+J.H.&author=Koo,+J.H.&author=Kim,+S.G.&publication_year=2016&journal=Mol.+Cell.+Biol.&volume=36&pages=1931%E2%80%931942&doi=10.1128/MCB.00118-16 https://scholar.google.com/scholar_lookup?title=Mitochondrial+complex+I+inhibitor+rotenone+induces+apoptosis+through+enhancing+mitochondrial+reactive+oxygen+species+production&author=Li,+N.&author=Ragheb,+K.&author=Lawler,+G.&author=Sturgis,+J.&author=Rajwa,+B.&author=Melendez,+J.A.&author=Robinson,+J.P.&publication_year=2003&journal=J.+Biol.+Chem.&volume=278&pages=8516%E2%80%938525&doi=10.1074/jbc.M210432200&pmid=12496265 https://www.ncbi.nlm.nih.gov/pubmed/15282312 https://creativecommons.org/licenses/by/4.0/https://scholar.google.com/scholar_lookup?title=Pathogenesis+of+Parkinson+disease-the+gut-brain+axis+and+environmental+factors&author=Klingelhoefer,+L.&author=Reichmann,+H.&publication_year=2015&journal=Nat.+Rev.+Neurol.&volume=11&pages=625%E2%80%93636&doi=10.1038/nrneurol.2015.197&pmid=26503923 https://doi.org/10.3390/md13063877 https://doi.org/10.1001/jamaneurol.2017.3299 https://scholar.google.com/scholar_lookup?title=Progression+of+motor+symptoms+in+Parkinson%E2%80%99s+disease&author=Xia,+R.&author=Mao,+Z.H.&publication_year=2012&journal=Neurosci.+Bull.&volume=28&pages=39%E2%80%9348&doi=10.1007/s12264-012-1050-z&pmid=22233888 https://scholar.google.com/scholar_lookup?title=Parkinson%E2%80%99s+Disease+and+the+Environment&author=Ball,+N.&author=Teo,+W.P.&author=Chandra,+S.&author=Chapman,+J.&publication_year=2019&journal=Front.+Neurol.&volume=10&pages=218&doi=10.3389/fneur.2019.00218&pmid=30941085 https://doi.org/10.3389/fneur.2019.00218 https://scholar.google.com/scholar_lookup?title=A+physiological+threshold+for+protection+against+menadione+toxicity+by+human+NAD(P)H:quinone+oxidoreductase+(NQO1)+in+Chinese+hamster+ovary+(CHO)+cells&author=De+Haan,+L.H.&author=Boerboom,+A.M.&author=Rietjens,+I.M.&author=van+Capelle,+D.&author=De+Ruijter,+A.J.&author=Jaiswal,+A.K.&author=Aarts,+J.M.M.J.G.&publication_year=2002&journal=Biochem.+Pharmacol.&volume=64&pages=1597%E2%80%931603&doi=10.1016/S0006-2952(02)01383-7&pmid=12429349 https://doi.org/10.1002/mds.25979 https://scholar.google.com/scholar_lookup?title=AMPK:+A+nutrient+and+energy+sensor+that+maintains+energy+homeostasis&author=Hardie,+D.G.&author=Ross,+F.A.&author=Hawley,+S.A.&publication_year=2012&journal=Nat.+Rev.+Mol.+Cell+Biol.&volume=13&pages=251%E2%80%93262&doi=10.1038/nrm3311&pmid=22436748 https://doi.org/10.1111/j.1365-2982.2008.01162.x https://scholar.google.com/scholar_lookup?title=Blood-brain+barrier-permeable+fluorone-labeled+dieckols+acting+as+neuronal+ER+stress+signaling+inhibitors&author=Kwak,+J.H.&author=Yang,+Z.&author=Yoon,+B.&author=He,+Y.&author=Uhm,+S.&author=Shin,+H.C.&author=Lee,+B.H.&author=Yoo,+Y.C.&author=Lee,+K.B.&author=Han,+S.-Y.&publication_year=2015&journal=Biomaterials&volume=61&pages=52%E2%80%9360&doi=10.1016/j.biomaterials.2015.04.045&pmid=25996411 https://scholar.google.com/scholar_lookup?title=p62/SQSTM1+is+a+target+gene+for+transcription+factor+NRF2+and+creates+a+positive+feedback+loop+by+inducing+antioxidant+response+element-driven+gene+transcription&author=Jain,+A.&author=Lamark,+T.&author=Sj%C3%B8ttem,+E.&author=Larsen,+K.B.&author=Awuh,+J.A.&author=%C3%98vervatn,+A.&author=McMahon,+M.&author=Hayes,+J.D.&author=Johansen,+T.&publication_year=2010&journal=J.+Biol.+Chem.&volume=285&pages=22576%E2%80%9322591&doi=10.1074/jbc.M110.118976&pmid=20452972 https://doi.org/10.1074/jbc.M513737200 https://www.ncbi.nlm.nih.gov/pubmed/26503923 https://doi.org/10.1007/s12264-012-1050-z https://www.ncbi.nlm.nih.gov/pubmed/30941085 https://scholar.google.com/scholar_lookup?title=Creatine+supplementation+with+exercise+reduces+a-synuclein+oligomerization+and+necroptosis+in+Parkinson%E2%80%99s+disease+mouse+model&author=Leem,+Y.-H.&author=Park,+J.-S.&author=Park,+J.-S.&author=Kim,+D.-E.&author=Kim,+H.-S.&publication_year=2024&journal=J.+Nutr.+Biochem.&volume=126&pages=109586&doi=10.1016/j.jnutbio.2024.109586 https://www.ncbi.nlm.nih.gov/pubmed/26096275 https://doi.org/10.1074/jbc.M210432200 https://scholar.google.com/scholar_lookup?title=Keap1+represses+nuclear+activation+of+antioxidant+responsive+elements+by+Nrf2+through+binding+to+the+amino-terminal+Neh2+domain&author=Itoh,+K.&author=Wakabayashi,+N.&author=Katoh,+Y.&author=Ishii,+T.&author=Igarashi,+K.&author=Engel,+J.D.&author=Yamamoto,+M.&publication_year=1999&journal=Genes+Dev.&volume=13&pages=76%E2%80%9386&doi=10.1101/gad.13.1.76 https://www.ncbi.nlm.nih.gov/pubmed/23205266 https://doi.org/10.1016/S0006-2952(02)01383-7 https://doi.org/10.1080/1028415X.2017.1294555 https://doi.org/10.1592/phco.27.12part2.155S https://www.ncbi.nlm.nih.gov/pubmed/28276272 https://www.ncbi.nlm.nih.gov/pubmed/20452972 https://doi.org/10.1074/jbc.M611336200 https://www.ncbi.nlm.nih.gov/pubmed/25996411 https://www.ncbi.nlm.nih.gov/pubmed/21234411 https://doi.org/10.1016/j.biomaterials.2015.04.045 https://scholar.google.com/scholar_lookup?title=Improvement+of+memory+by+dieckol+and+phlorofucofuroeckol+in+ethanol-treated+mice;+possiblle+involvement+of+the+inhibition+of+acetylcholineesterase&author=Myung,+C.S.&author=Shin,+H.C.&author=Bao,+H.Y.&author=Yeo,+S.J.&author=Lee,+B.H.&author=Kang,+J.S.&publication_year=2005&journal=Arch.+Pharm.+Res.&volume=28&pages=691%E2%80%93698&doi=10.1007/BF02969360 https://doi.org/10.1016/j.bbagen.2012.02.008 https://www.ncbi.nlm.nih.gov/pubmed/29131880 https://doi.org/10.1007/BF02969360 https://scholar.google.com/scholar_lookup?title=Oxidative+stress+in+the+aging+substantia+nigra+and+the+etiology+of+Parkinson%E2%80%99s+disease&author=Trist,+B.G.&author=Hare,+D.J.&author=Double,+K.L.&publication_year=2019&journal=Aging+Cell&volume=18&pages=e13031&doi=10.1111/acel.13031 https://doi.org/10.1007/BF02976957 https://scholar.google.com/scholar_lookup?title=Parkinson%E2%80%99s+Disease+and+Pesticides+Exposure:+New+Findings+from+a+Comprehensive+Study+in+Nebraska,+USA&author=Wan,+N.&author=Lin,+G.&publication_year=2016&journal=J.+Rural+Health&volume=32&pages=303%E2%80%93313&doi=10.1111/jrh.12154 https://www.ncbi.nlm.nih.gov/pubmed/37305552 https://scholar.google.com/scholar_lookup?title=The+Nrf2/ARE+Pathway:+A+Promising+Target+to+Counteract+Mitochondrial+Dysfunction+in+Parkinson%E2%80%99s+Disease&author=Tufekci,+K.U.&author=Civi+Bayin,+E.&author=Genc,+S.&author=Genc,+K.&publication_year=2011&journal=Park.+Dis.&volume=2011&pages=314082&doi=10.4061/2011/314082 https://doi.org/10.1007/s11010-020-03824-5 https://www.ncbi.nlm.nih.gov/pubmed/18041935

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