Physical fitness and lifestyles associated with biological aging | Aging

Relationship between physical fitness and biological age, based on DNAm aging clocks, is poorly understood.

Relationship between cardiorespiratory fitness and lifestyle-related factors with DNA methylation-based ageing clocks in older men: WASEDAâS Health Study.

We found that CRF was negatively related to epigenetic age acceleration, even after adjusting for confounders (chronological age, smoking, and alcohol consumption), and that maintenance of CRF above a reference value (i.e., 22.7 mL/kg/min ) was associated with lower age acceleration.

The study did not account for all possible confounders that may influence the relationships between CRF , lifestyle-related factors, and biological aging.

Future studies are needed to consider sex, ethnicity, genetic predisposition, and socioeconomic status.

Exercise-related geroscience research is currently in its infancy; thus, a steady accumulation of evidence is required.

In mouse studies, late-life exercise training could delay epigenetic aging of skeletal muscle.

Res Q Exerc Sport . 2023 ; 19:1â11.2228388 .

Cell Metab . 2024 ; 36:278â300 . https://doi.org/10.10.0101367.008 [PubMed] - 11.0128388 [Pubmed].