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epigenetic aging resultsAging
•90% Informative
DNA methylation-based epigenetic clocks are used as biomarkers of biological age in human health.
The underlying mechanisms of these clocks remain poorly understood, leading to potential misinterpretations of their associations with health outcomes.
The relationship between epigenetic age and health outcomes is often viewed through a narrow lens.
Although universal epigenetic aging marks may exist, modeling them accurately across cell types at the bulk tissue level is complicated by age-related changes in cell composition.
Pan-tissue epigenetic clock development faces challenges due to inadequate training samples, with blood samples predominating in training datasets.
EpiTOC, for instance, functions as a mitotic clock, estimates stem cell divisions, and correlates with increased cancer risk.
KonceviÄius K , et al. Aging Cell. 2024 ; e14170. [Epub ahead of print]. [PubMed] - 10.1186/s13059-016-1064-3 [Pubmed] - 11.1101/gr.233213.117.
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