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drug resistanceAging
•80% Informative
Targeted cancer therapy: the initial high concentration may slow down the selection for resistance - 1 Roswell Park Comprehensive Cancer Center, Buffalo , NY 14263 , USA .
To ensure rapid selection of drug resistance in the cell culture, we first treat cancer cells with low drug concentrations, increasing drug concentrations over time.
In patients, treatment with targeted drugs is mistakenly designed to expedite the selection of resistance.
To decelerate the acquisition of drug resistance, targeted therapy must target the tumor at a higher than steady-state drug concentration.
Rapamycin may activate MEK , and Trametinib may activate the mTOR pathway.
Starting treatment with a higher dose is common in medicine. For instance, starting with high doses is typical for antibacterial antibiotics.
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