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•80% Informative
Microglia establish connections with neurons through tunneling nanotubes.
These tubes facilitate the clearance of toxic proteins from neurons and to promote neuronal health.
The accumulation of pathological proteins is a hallmark of several neurodegenerative disorders, including Alzheimer's disease, frontotemporal dementia and Parkinson's disease.
The researchers observed that microglia can effectively alleviate neurons from toxic protein burdens but also transfer mitochondria toward affected neurons via the same TNTs.
The results open promising avenues when it comes to understanding the brain and its associated diseases.
Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes.
Neuron , 2024 ; DOI: 10.1016 /j.neuron.029.
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