APOE3 Christchurch Variant Protects Alzheimer's

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protective genetic variants

Mass General Brigham | Integrated Health Care System

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Study Finds One Copy of Protective Genetic Variant Helps Stave Off Early-Onset Alzheimer’s Disease

Summary

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In an extended family with an inherited form of early-onset Alzheimer’s disease, 27 family members who carried one copy of the APOE3 Christchurch genetic variant had a five-year delayed disease onset compared to those who did not have the variant.

Previously, researchers identified the “ Christchurch variant” as potentially protective against Alzheimer's based on one family member who had two copies of this variant and was expected to develop dementia in her 40s .

Mass General Brigham connects a full continuum of care across a system of academic medical centers, community and specialty hospitals, a health insurance plan, physician networks, community health centers, home care, and long-term care services.

The system is one of the nation’s leading biomedical research organizations with several Harvard Medical School teaching hospitals.

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