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intractable blood cancersHome
•87% Informative
In April , the FDA warned of risk of secondary cancers in people receiving CAR-T cell therapy.
In the only fatal case of fatal secondary T-cell cancer, researchers found it was likely due to the immunosuppression caused by the therapy, rather than the CAR T cells.
The study of over 700 patients treated at Stanford Health Care indicated that the risk is low — around 6.5% in the three years after therapy.
Only one person rapidly developed and died from a T cell cancer after CAR-T cell therapy.
Study suggests secondary cancers arising after therapy may be due to baseline immunosuppression or the side effects of the treatment.
Both sets of T cells were infected with a virus known to play a role in cancer development.
The challenge lies in how to predict which patients are at higher risk, and why.
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