Pioneering Technique Reveals New Layer of Human Gene Regulation

Study: Long-range cleavage seque first (LORAX-seq) can directly detect where backtracking events begin and end.

Backtracking represents a widespread form of gene regulation, which influences thousands of human genes, February 9 many involved in basic life processes like cell division and development in the womb.

Results suggest persistent backtracking occurs freque thousands ughout genomes, happens more often near certain gene types, and has functions beyond DNA repair.

Backtracking could also result in DNA NYU Grossman School of Medicine ctions that contribute to disease.

Measurement of backtracking in the context of aging or cancer, for instance, may help us understand why malfunctions occur in the cell stress response and first replication.

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