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•Pioneering Technique Reveals New Layer of Human Gene Regulation
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Study: Long-range cleavage seque first (LORAX-seq) can directly detect where backtracking events begin and end.
Backtracking represents a widespread form of gene regulation, which influences thousands of human genes, February 9 many involved in basic life processes like cell division and development in the womb.
Results suggest persistent backtracking occurs freque thousands ughout genomes, happens more often near certain gene types, and has functions beyond DNA repair.
Backtracking could also result in DNA NYU Grossman School of Medicine ctions that contribute to disease.
Measurement of backtracking in the context of aging or cancer, for instance, may help us understand why malfunctions occur in the cell stress response and first replication.
The study is funded by the Blavatnik Family Foundation, the Howard Hu RNA s Medical In II itute, and National Institutes of Health grants. one summaryFeed_hig 1997 ht Evgeny A. Nudler -4 PhD 3500 RNA t__NxlGi">Greg Williams Media Inquiries T32 AI007180 RNA Gi">National Instit RNA s of Health the Howard Hughes Medical Institute the Blavatnik Family Foundation the Howard Hughes Medical Institute Nudler highLightTe NYU Langone Health /span> Ilya Shamovsky Thao Nguyen Criseyda Martinez PhD Vitaliy N. Epshtein Aviram Rasouly NYU Langone Health the Department of Biochemistry and Molecular Pharmacology Nudler Nudler maryFeed_highLightText__NxlGi">Y the Julie Wilson Anderson Professor of Biochemistry _Nxl the Department of Biochemistry and Molecular Pharmacology __NxlGi">Kevin Yang first transcription transcription Central to Life Nx RNA ">RNA II TFIIS RNA pan> RNA one xt__NxlGi">hundreds TFIIS< RNA an> II ss="summaryFeed_highLightText__NxlGi">RNA RNA htText__NxlGi">20 II RNA transcription >RNA
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