広島大学
•78% Informative
AXL heterodimerizes with EGFR to activate the EGFR -LATS1/2-YAP axis, resulting in proliferation and resistance against drugs.
Scientists from Hiroshima University Hospital clarified the mechanism by which AXL activates YAP.
The team determined that the combination of AXL and EGFR inhibitors working together inactivates YAP and suppresses the viability of head and neck squamous cell carcinoma.
AXL activates YAP through the EGFRLATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma.
Research is funded by Japan Science and Technology Agency (JST) SPRING , Hiroshima University Foundation , and JST HIRAKU-Global program.
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