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Protein engineers navigate toward more targeted therapeutics

89% Informative
More than a third of FDA-approved drugs work by targeting a G protein-coupled receptor, or GPCR.
Drugs that either block or activate GPCRs are used to treat a wide range of diseases including hypertension, pain and inflammation.
University of Minnesota researchers have uncovered the role of the third intracellular loop in the receptor's signaling mechanism.
The loop is highly unique, even among closely related receptors, making it an outstanding drug target.
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94
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English
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