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Protein engineers navigate toward more targeted therapeutics

Phys Org
Summary
Nutrition label

89% Informative

More than a third of FDA-approved drugs work by targeting a G protein-coupled receptor, or GPCR.

Drugs that either block or activate GPCRs are used to treat a wide range of diseases including hypertension, pain and inflammation.

University of Minnesota researchers have uncovered the role of the third intracellular loop in the receptor's signaling mechanism.

The loop is highly unique, even among closely related receptors, making it an outstanding drug target.

VR Score

94

Informative language

98

Neutral language

37

Article tone

formal

Language

English

Language complexity

65

Offensive language

not offensive

Hate speech

not hateful

Attention-grabbing headline

not detected

Known propaganda techniques

not detected

Time-value

long-living

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