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affective pain pathwayScienceDaily
•Health
Health
77% Informative
Salk scientists uncover a key neural circuit in mice that gives pain its emotional punch.
Breakthrough sheds light on why some people suffer more intensely than others from conditions like fibromyalgia, migraines, and PTSD.
By identifying the exact group of neurons that link physical pain to emotional suffering, the researchers may have found a new target for treating chronic pain.
Salk Institute's Sung Han says overactivation of the CGRP spinothalamic pathway may contribute to these conditions by making the brain misinterpret or overreact to sensory inputs.
Han sees potential relevance for psychiatric conditions that involve heightened threat perception, such as PTSD.
Quieting this pathway could offer a new approach to easing fear, avoidance, and hypervigilance in trauma-related disorders.
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